LAL-D Insights

Lysosome illustration

Evolving Perspectives on the Role of Lysosomes in Maintaining Cellular Homeostasis

Lysosomal storage diseases, including lysosomal acid lipase deficiency, were first described in the 19th century, even before lysosomes were clearly defined in biology. They were initially characterized as a group of symptoms—as opposed to the molecular diagnosis we use today.  “Knowledge on lysosomal storage diseases has been evolving for more than a century,” Parenti and…

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