The Prevalence of Liver Disease in Patients With Alagille Syndrome
Liver disease is one of the most common manifestations of Alagille syndrome and contributes significantly to healthcare utilization.
ALGS Insights
Drug Repurposing: A Novel Strategy for a Deeply Unequal World
The belief driving drug repurposing is that the current drugs that we do have may yet possess therapeutic aspects we aren’t fully aware of.
Case Study: Arterial Stenoses in Alagille Syndrome
Researchers present the case study of a patient who presented with multiple arterial stenoses and was later diagnosed with Alagille syndrome.
The Vital Importance of Liver Transplantation in Patients With ALGS
Liver transplantation is often urgently required in patients with Alagille syndrome and end-stage liver disease.
Hepatocellular Carcinoma From a Background of Alagille Syndrome
Patients who are diagnosed with Alagille syndrome early in life may develop hepatocellular carcinoma much later.
Regenerative Liver Medicine Could Help Overcome Transplant Limitations
Liver organoids have been used to regenerate hepatocellular parenchyma and bile ducts, providing a convenient platform for research and clinical purposes.
Improving the Timely Diagnosis of ALGS by Understanding Its Characteristic Features
Congenital genetic diseases sometimes display characteristic clinical manifestations that direct physicians to conduct the necessary tests to arrive at a correct diagnosis. However, other genetic diseases may be more insidious and are diagnosed only later in life (if at all), which means the early window for the initiation of critical medical intervention is missed. When…
A Rare Co-occurrence of Alagille Syndrome and von Willebrand Disease
In the South African Journal of Child Health, Dempster and colleagues detail the case of a patient who was simultaneously diagnosed with 2 rare disorders: Alagille syndrome and von Willebrand disease. A 17-year-old female patient presented with hypochromic anemia and splenomegaly. She had been diagnosed with Alagille syndrome in infancy due to having characteristic features…
Alagille Syndrome May Cause Significant Cardiac Anomalies, Even Without Liver Involvement
Although Alagille syndrome is a multisystem disease, occasionally it can affect one organ more prominently than others.
Managing the Oral Manifestations of Alagille Syndrome
Oral manifestations of Alagille syndrome, such as the greenish discoloration of the teeth, can be psychologically distressing to patients.
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