Archives: HCP Resource

hATTR types

Hereditary Transthyretin Amyloidosis Types

Hereditary amyloidosis consists of a group of genetic diseases in which amyloid fibrils form and deposit in several organs and tissues in the body, causing them to malfunction.1 The most common type of hereditary amyloidosis is associated with mutations in the transthyretin (TTR) gene, which encodes the TTR protein.1,2  Hereditary Transthyretin Amyloidosis Phenotypes Hereditary transthyretin…

hATTR signs and symtoms

Hereditary Transthyretin Amyloidosis Signs and Symptoms

Hereditary transthyretin-mediated amyloidosis (hATTR) is a degenerative, progressive, fatal disease involving multiple organs and tissues. The disease occurs due to misfolded transthyretin (TTR) protein.1 Long before symptoms appear, amyloid fibrils start to accumulate. The disease can affect various organ systems and body tissues as it worsens. While the disease’s progression is varied, some signs and…

hATTR Life Expectancy

Hereditary ATTR (hATTR) Amyloidosis Life Expectancy

Hereditary transthyretin-related (hATTR) amyloidosis is a rare, severe, inheritable, debilitating disease that tends to affect the peripheral and autonomic nervous system, heart, gastrointestinal system, and eyes. Mutations in the transthyretin (TTR) gene, inherited in an autosomal-dominant pattern, lead to the deposition of amyloid fibrils in multiple organs, which causes somatic and autonomic neuropathy, cardiomyopathy, and…

hATTR History

Hereditary Transthyretin Amyloidosis History

Hereditary transthyretin amyloidosis (hATTR) is a systemic and progressive disease that derives from mutations in the transthyretin (TTR) gene that lead to the formation and deposit of amyloid fibers in organs and tissues. Amyloid fibers most often accumulate in the peripheral nerves (hATTR with polyneuropathy) and heart (hATTR with cardiomyopathy), although other organs and tissues,…

hATTR diet and nutrition

Hereditary ATTR Amyloidosis Diet and Nutrition

Hereditary transthyretin (hATTR) amyloidosis is a rare genetic condition characterized by the abnormal accumulation of amyloid proteins throughout the body, particularly in the nervous and cardiac systems. hATTR amyloidosis may also affect the kidneys, eyes, and gastrointestinal tract. Common manifestations of this disease include progressive peripheral neuropathy, cardiomyopathy progressing to heart failure, and autonomic dysfunction,…