Sheila Jacobs

Sheila Jacobs is the president of STJ Editorial Services. For more than 25 years, Sheila has been providing writing, fact-checking, and editorial services to numerous clients in the medical education, promotional, and managed care arenas, from the conceptual stage through completion of the final editorial product. Her focus has been in a diverse array of therapeutic areas.

All articles by Sheila Jacobs

Digoxin bottle

Chronic Digoxin Use in PAH Does Not Reduce All-Cause Mortality

In patients with pulmonary arterial hypertension (PAH), chronic use of digoxin is linked to greater all-cause mortality and hospitalization for heart failure, according to findings from the single-center Minnesota Pulmonary Hypertension Repository (MPHR) published in the Journal of the American Heart Association. Among individuals with PAH, increased right ventricular (RV) afterload is associated with RV…

Right ventricle-highlighted heart

Right Ventricular Metabolic Alterations in PAH May Be Predictive of Clinical Decline

In individuals with pulmonary arterial hypertension (PAH), mild changes in right ventricular (RV) glucose metabolism may be associated with patient prognosis, according to findings from a positron emission tomography/magnetic resonance imaging (PET/MRI) hybrid imaging follow-up study published in EJNMMI Research. Among those with undiagnosed or poorly managed PAH, progressive increases in RV afterload that result…

Paroxysmal Nocturnal Hemoglobinuria

Eculizumab Not Linked to Optimal Clinical Outcomes in Patients With PNH

In individuals with paroxysmal nocturnal hemoglobinuria (PNH), treatment with eculizumab is not associated with optimal clinical outcomes, with patients continuing to experience an ongoing burden of disease, according to findings from a retrospective study published in the European Journal of Haematology. Patients with PNH suffer hemolysis, with an elevated risk for thrombosis, along with a…

Gloved hands holding tests tubes with blood

rFIXFc Use in Patients With Hemophilia B Found to Be Safe and Effective

In individuals with severe hemophilia B, the use of recombinant factor IX Fc fusion protein (rFIXFc) was associated with sustained clinical benefits, including complete resolution of target joints and long-term bleed prevention, according to findings from a post hoc analysis of pooled longitudinal data published in Blood Advances. In patients with severe hemophilia B, the…

Monoclonal antibodies

Daratumumab Seen as Effective in Patients With Refractory Acquired Hemophilia A

In patients with acquired hemophilia A (AHA), clearance of factor VIII (FVIII) inhibitors is needed with treatment, particularly in those with refractory disease, according to findings from 4 case reports published in the Journal of Thrombosis and Haemostasis. Individuals with AHA are prone to experiencing episodes of bleeding, which are associated with a decrease in…

CFTR gene

Lumacaftor/Ivacaftor May Modify Early Pediatric CF Disease Progression

In children 2 years of age or older with cystic fibrosis (CF), treatment with lumacaftor/ivacaftor (LUM/IVA) early in the disease course may modify disease progression, according to findings from a phase 2, placebo-controlled trial published in Annals of the American Thoracic Society. Among individuals with CF, mutations in the gene that encodes the CF transmembrane conductance…

Illustration of spleen inside human

Splenectomy in Adults With Sickle Cell Disease Leads to Increased Risk for VTEs

Adult patients with sickle cell disease (SCD) who undergo a splenectomy are at increased risk for venous thromboembolic events (VTEs), according to findings from an observational, retrospective study published in the British Journal of Haematology. About 30% of individuals with SCD may require a surgical splenectomy because of such unpredictable complications as acute splenic sequestration…

Knee connective tissue

Survival Rates in Chinese Patients With PAH Associated With CTD

Among patients with pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD-PAH), 10-year survival rates are poor, according to findings from a study derived from a Chinese national multicenter, prospective registry and published in Rheumatology. The researchers sought to accomplish the following: Individuals who had undergone right heart catheterization within 1 month prior to…

Cardiovascular system

Some Vascular Problems Can Affect Survival After Pediatric Liver Transplantation

Pediatric liver transplantation is performed for a variety of indications, including Alagille syndrome (ALGS), biliary atresia, hepatoblastoma, and metabolic liver disease, researchers wrote in a retrospective study published in the journal Digestive and Liver Diseases. They sought to examine data on how posttransplant complications affected long-term survival and quality of life among children who had…

Dentist at work with tools

Steps to Improve Outcomes After Dental Extractions in Patients With Hemophilia

In patients with hemophilia A or B who undergo dental extractions, the use of hemostatic treatments and factor prophylaxis is associated with decreased rates of bleeding, according to findings from a retrospective analysis published in the Journal of Clinical Medicine. Among patients with hemophilia, dental extractions are frequently associated with bleeding and the need for…

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