Researchers measured plasma concentrations of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) in patients with sickle cell disease (SCD) and malaria to determine their total body load of P falciparum parasites and published their results in The Lancet Child & Adolescent Health. Uyoga et al conducted a post hoc secondary analysis of data from the Transfusion…
Researchers discovered a statistical correlation between nerve invasion and aggressive histopathological subtypes of thyroid cancer and published their results in Cancers. The retrospective study consisted of 52 patients who underwent resection of the recurrent nerve for primary or recurrent follicular cell-derived or medullary thyroid carcinoma (MTC) from 2005 to 2020. Nerve involvement has been shown…
Researchers compared procedural bleeding rates and systemic hemostatic treatment use before and after the introduction of a risk-based standardized treatment protocol for bleeding prevention in dental procedures, as published in Haemophilia. The retrospective review of dental procedures was conducted in patients with hemophilia and various other inherited bleeding disorders, and it compared patient outcomes before…
Researchers in Poland explored cardiovascular autonomic dysfunction in patients with myasthenia gravis (MG) by utilizing various testing methods and published their results in the Journal of Clinical Medicine. They included 38 patients with MG whose cardiovascular autonomic testing results were compared with those of 30 age- and gender-matched controls. The study recorded participants’ cardiovascular parameters,…
Researchers discovered the radiological features and mucin (MUC) immunohistochemical expression patterns of a recent case of amphicrine medullary thyroid carcinoma (MTC) and published their results in Endocrine Pathology. Intra- and extracellular MUC production has been variably documented in benign and malignant thyroid tumors. While the expression and contribution of MUC1 have been significantly studied in…
Researchers suggest that immunodeficient patients with lysosomal storage diseases (LSDs) such as Pompe disease (PD) do not have a higher risk of contracting COVID-19 infection in comparison to the healthy population, as published in Archives de Pediatrie. While the potential increase in risk for COVID-19 in these patients is emphasized in the literature, this study…
Researchers have developed a comprehensive, combined deep learning and machine learning algorithm that can be used to easily, rapidly, and noninvasively diagnose and differentiate idiopathic pulmonary fibrosis (IPF) from various other interstitial lung diseases (ILDs), as published in Respirology. The researchers used noninvasive clinical examination and high-resolution computed tomography (HRCT) to develop a multimodal artificial…
Patients with hemophilia often use a symptom-based algorithm to self-diagnose hemarthrosis to initiate timely and appropriate management. A new study published in Haemophilia validated these questionnaires by using objective point-of-care musculoskeletal ultrasound imaging modalities. This study evaluated a “painful episode questionnaire” which was developed by the Canadian Haemophilia Society as a tool to distinguish acute…
The enhanced clinical benefits of alpha-1 antitrypsin (AAT) therapy in severe AAT deficiency (AATD) were identified in a new study published in the American Journal of Respiratory Critical Care Medicine. While AAT therapy reduces protease-mediated lung tissue destruction and retards emphysema progression, there is also growing evidence regarding the anti-inflammatory and immunomodulatory properties of AAT.…
Researchers conducted an open-label extension of the initial phase 1 trial evaluating the safety and efficacy of long-term sutimlimab, a monoclonal antibody targeting the C1s protein of the classical complement pathway, in 4 patients with cold agglutinin disease (CAD) and published their results in the British Journal of Haematology. The patients were all female, Caucasian,…
