Collaborating researchers from various departments at Duke University, Durham, North Carolina, have found that tongue weakness and structural changes, such as atrophy, could hint at late-onset Pompe disease (LOPD) and help differentiate it from other acquired or hereditary causes of myopathy. The study findings could have considerable implications on the clinical approach to LOPD. Late-onset…
Infantile-onset Pompe disease (IOPD) is a fatal glycogen storage disease caused by a deficiency of the enzyme acid alpha-glucosidase (GAA), which leads to an accumulation of glycogen and skeletal, cardiac, and smooth muscle damage. IOPD is treated with recombinant human GAA (rhGAA, alglucosidase alfa) enzyme replacement therapy (ERT), which can significantly improve clinical outcomes. However,…
A new mouse model study at the University of Iowa has found that a diet rich in isoflavone, a phytoestrogen, might protect against multiple sclerosis (MS). The same study team previously found that isoflavone-metabolizing gut bacteria are less abundant in patients with MS. The present study findings were published in Science Advances and highlight the…
