Omar Baqal, MBBS

All articles by Omar Baqal, MBBS

Cardiac Autonomic Dysfunction Linked With Parasympathetic Impairment in MG

Researchers in Poland explored cardiovascular autonomic dysfunction in patients with myasthenia gravis (MG) by utilizing various testing methods and published their results in the Journal of Clinical Medicine. They included 38 patients with MG whose cardiovascular autonomic testing results were compared with those of 30 age- and gender-matched controls. The study recorded participants’ cardiovascular parameters,…

Researchers Uncover Novel Pathology of Amphicrine Phenotype in MTC

Researchers discovered the radiological features and mucin (MUC) immunohistochemical expression patterns of a recent case of amphicrine medullary thyroid carcinoma (MTC) and published their results in Endocrine Pathology. Intra- and extracellular MUC production has been variably documented in benign and malignant thyroid tumors. While the expression and contribution of MUC1 have been significantly studied in…

COVID19 virus

Real-Life Data Show Risk of Contracting COVID-19 in Pompe Disease

Researchers suggest that immunodeficient patients with lysosomal storage diseases (LSDs) such as Pompe disease (PD) do not have a higher risk of contracting COVID-19 infection in comparison to the healthy population, as published in Archives de Pediatrie. While the potential increase in risk for COVID-19 in these patients is emphasized in the literature, this study…

Human lungs

Newly Developed Algorithm Differentiates IPF From Other Lung Diseases

Researchers have developed a comprehensive, combined deep learning and machine learning algorithm that can be used to easily, rapidly, and noninvasively diagnose and differentiate idiopathic pulmonary fibrosis (IPF) from various other interstitial lung diseases (ILDs), as published in Respirology. The researchers used noninvasive clinical examination and high-resolution computed tomography (HRCT) to develop a multimodal artificial…

Artificial intelligence

Patient-Derived Tool Validates Hemarthrosis With Musculoskeletal Imaging

Patients with hemophilia often use a symptom-based algorithm to self-diagnose hemarthrosis to initiate timely and appropriate management. A new study published in Haemophilia validated these questionnaires by using objective point-of-care musculoskeletal ultrasound imaging modalities. This study evaluated a “painful episode questionnaire” which was developed by the Canadian Haemophilia Society as a tool to distinguish acute…

cytokines

Cytokine Regulation Among the Benefits of Alpha-1 Antitrypsin Therapy in AATD

The enhanced clinical benefits of alpha-1 antitrypsin (AAT) therapy in severe AAT deficiency (AATD) were identified in a new study published in the American Journal of Respiratory Critical Care Medicine.  While AAT therapy reduces protease-mediated lung tissue destruction and retards emphysema progression, there is also growing evidence regarding the anti-inflammatory and immunomodulatory properties of AAT.…

hemoglobin G

Sutimlimab Improves Hemoglobin Levels in CAD, Study Finds

Researchers conducted an open-label extension of the initial phase 1 trial evaluating the safety and efficacy of long-term sutimlimab, a monoclonal antibody targeting the C1s protein of the classical complement pathway, in 4 patients with cold agglutinin disease (CAD) and published their results in the British Journal of Haematology. The patients were all female, Caucasian,…

retinal

Retinal Layer Thinning Predicts Long-Term Disability in MS

Researchers discovered that ganglion cells plus the inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) measurements predict physical and cognitive neurodegeneration in patients with multiple sclerosis (MS) after 6 years, as published in the Multiple Sclerosis Journal. GCIPL and pRNFL thinning correlate with physical and cognitive disability progression and are established biomarkers…

thyroid cancer cells

Lactic Acidosis Promotes Aggressive Features in Cholangiocarcinoma

Researchers found an increase in cancer aggressiveness in cholangiocarcinoma (CCA) cells exposed to lactic acidosis due to the upregulation of ALDH1A3, as published in Life Sciences. The team derived information on ALDH1A3 expression in CCA cells from the Gene Expression Omnibus datasets. They also used several human CCA cell lines to demonstrate increased ALDH1A3 expression…

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