Michael Nace, MA

All articles by Michael Nace, MA

Adult juvenile rheumatoid arthritis (Still's disease)

I. What every physician needs to know. This inflammatory disorder characterized by daily high fevers, arthritis, and an evanescent rash in children was originally described in 1896 by George Still. Since then, it has been known by various other names in adults: Adult-onset Still’s disease (AOSD) Adult juvenile rheumatoid arthritis (adult JRA) – in the…

Alpha-1-Antitrypsin Deficiency

OVERVIEW: What every practitioner needs to know Are you sure your patient has alpha-1-antitrypsin deficiency? What are the typical findings for this disease? Alpha-1-antitrypsin (a1AT) deficiency is an autosomal, co-dominant genetic disease most commonly caused by homozygosity for the Z mutant of the a1AT gene. These patients are called ZZ, or PIZZ in WHO nomenclature.…

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