Leonardo Jaimes, MD

Leonardo Jaimes, MD, is a Venezuelan medical doctor with teaching experience in the field of immunology currently working as a general practitioner and in the field of telehealth.

All articles by Leonardo Jaimes, MD

Data Support Intraoperative Revision of Biliary Margins in CCA

Intraoperative revision of margins from frozen sections could increase overall survival (OS) in patients with perihilar cholangiocarcinoma (CCA), according to a study recently published in Annals of Surgical Oncology. “Achieving a margin-negative resection (R0) is challenging given the anatomic location of tumors and remains the most important prognostic indicator of long-term survival,” the authors wrote.…

total knee arthroplasty

Study Finds Several Factors Influence Blood Loss in Hemophilia Knee Arthroplasty

Age appears to be directly correlated with increased hidden blood loss after total knee arthroplasty (TKA) in patients with hemophilia A, while tranexamic acid and factor VIII (FVIIII) infusion may decrease the risk of bleeding after the procedure, according to a recently published study in BMC Musculoskeletal Disorders. TKA is a common treatment for hemophilia-related arthropathy,…

Lymphocyte

BOS-318 Inhibitor Shows Mutation-Agnostic Properties in CF

The use of BOS-318 in human ex vivo models has shown an increase in airway hydration, mucociliary clearance, and protection against epithelial cell death due to Pseudomonas aeruginosa infection, therefore suggesting a potential therapeutic value in cystic fibrosis (CF), as published in Cell Chemical Biology. The pathogenesis of CF is associated with an epithelial sodium channel…

dendritic cell

Monocyte and Dendritic Cell Abnormalities Correlate With SM

Innate immune cells such as dendritic cells and monocytes may contribute to cytokine imbalance and immune dysregulation in patients with systemic mastocytosis (SM), according to a recently published study in Clinical and Translational Allergy. Although mast cells are the key cells involved in SM pathogenesis, increasing new evidence suggests that mast cells are not the only…

infusion bottle

Drug-Eluting Beads With Systemic Therapy Shows Promise for CCA

The concomitant use of drug-eluting bead, irinotecan therapy (DEBIRI), and chemotherapy with gemcitabine/cisplatin may increase survival in patients with unresectable intrahepatic cholangiocarcinoma (CCA), according to results of a multicenter, randomized phase 2 clinical trial. Although the preferred approach to CCA is surgical resection, most patients are not eligible for surgery due to advanced disease progression.…

Study Shows High Polypharmacy in Older Patients With Hemophilia

Polypharmacy, defined as the use of 5 or more medications per day, has a high prevalence among patients with bleeding disorders such as hemophilia and von Willebrand disease (vWD), according to a recently published multicenter prospective observational study. Polypharmacy is a frequent problem for individuals older than 65 years. Due to the success of replacement…

vertebrae

Study Finds Decreased Vertebral Height in Children With SMA

Newly characterized anatomic variations in the vertebral bodies of children with spinal muscular atrophy (SMA) may not only explain the spinal deformity frequently seen in these patients, but also influence their treatment, according to a study recently published in World Neurosurgery. “Surgeons should be aware of anatomical differences for choosing implant devices accordingly,” the authors…

Guidelines

A New Consensus on Managing Liver Cirrhosis Complications in Children

A group of experts recently gathered to produce a consensus on the appropriate management of complications related to liver cirrhosis (LC) in children; the resulting guideline was published in the Journal of Mexican Gastroenterology.  The causes of LC in childhood are varied, ranging from genetic disorders such as Alagille syndrome to viral infections like hepatitis…

injection

ERT Is Safe but With Variable Effectiveness in Pompe Disease, Study Says

Patients with late-onset Pompe disease (PD) who received enzyme replacement therapy (ERT) of alglucosidase alfa presented no adverse effects, however, showed varied responses to treatment, according to a retrospective observational study published in Medical Clinics. The study included 22 individuals: 5 patients with late-onset PD, 6 with type C Niemann-pick disease, 8 with type 1…

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