Juliette Siegfried, MPH

Juliette Siegfried, MPH

Juliette Siegfried, MPH is a biomedical writer, editor, and translator who has worked in health communications for over 30 years. After working as a health communications specialist for the National Institutes of Health in Bethesda, MD, Juliette moved to Madrid, Spain, and established ServingMed.com, a small medical editing, writing, and translating business to help hospitals, universities, and individual health care professionals publish their work in English. In 2010 Juliette moved with her family to the Netherlands, where she currently manages a team of 3 writer-editor-translators and serves an expanded clientele around the globe.

All articles by Juliette Siegfried, MPH

Treatment of AATD

Augmentation Therapy Reduces Exacerbations in Case of AATD With Bronchiectasis

Researchers have reported a case in which a patient’s exacerbations of alpha-1 antitrypsin deficiency were successfully reduced with the use of augmentation therapy. The case report, published in Respiratory Medicine Case Reports, noted that the patient also had bronchiectasis and suggested that clinicians should consider AATD as a possible cause of this condition. “Whilst there…

physician patient form

Advanced SM Initially Presents With a Wide Range of Symptoms, Complicating Diagnosis

A new study has characterized the symptomatology of patients with advanced systemic mastocytosis (SM) as reported by oncologists at the first patient visit. The study, published in Clinical Lymphoma, Myeloma & Leukemia, found a wide range of symptoms, comorbid conditions, and diagnostic strategies for these patients. “Although driven by KIT D816V in 95% of cases,…

subcutaneous injection

Rondoraptivon Pegol Increases Factor VIII Half-Life and Levels in Hemophilia A Patients

A new study has found that the von Willebrand factor (VWF)-binding aptamer rondoraptivon pegol increased the half-life of substituted factor VIII (FVIII) as well as endogenous FVIII levels in patients with hemophilia A. The study, published in Blood, also found that the patients tolerated the subcutaneous treatment well. “Recently, rondoraptivon pegol (previously BT200), a VWF-binding…

technician placing a sample on assay tube

Droplet Digital PCR Might Be a Useful Alternative for Detecting SM

A new study assessed droplet digital polymerase chain reaction (ddPCR) as an alternative diagnostic tool to allele-specific oligonucleotide real-time quantitative PCR (ASO-qPCR) to detect the D816V KIT mutation in patients with suspected systemic mastocytosis (SM). The study, published in Clinical Lymphoma, Myeloma & Leukemia, found that ddPCR could reliably detect the mutation in a noninvasive…

clinical trial

Phase 3 AFFINE Study of Novel Gene Therapy for Hemophilia Reopens Recruitment

The Pfizer and Sangamo Therapeutics phase 3 AFFINE study assessing the efficacy and safety of giroctocogene fitelparvovec, a novel gene therapy for patients with moderately severe to severe hemophilia A, has reopened recruitment. The reopening, announced by news release, will resume enrollment this month and dosing is expected to restart in October. Giroctocogene fitelparvovec is…

Lanadelumab May Be Effective as Long-Term Prophylactic Therapy in Patients With HAE

A new report on 2 patients with hereditary angioedema (HAE) with normal C1-inhibitor (C1-INH) and factor XII mutation (nC1-FXII) found that the administration of lanadelumab, a human immunoglobulin recombinant monoclonal antibody, was effective in preventing attacks. The report, published in the Annals of Allergy, Asthma & Immunology, suggests that larger studies on this medication are…

Deep learning illustration

Unsupervised Machine Learning Can Identify IPF Progression Markers

A new study has found that unsupervised machine learning is able to determine radiological disease progression markers in patients with idiopathic pulmonary fibrosis (IPF). The study, published in European Radiology, also observed pattern transitions that revealed a sequence of tissue types from healthy to advanced disease. “Besides the difficulties in diagnosing IPF, the prediction of…

woman coughing

Patients With AATD May Not Recognize Symptom Changes as Exacerbations

A new study has found that patients with alpha-1 antitrypsin deficiency (AATD) may not identify changes in their pulmonary symptoms as exacerbations. The study, published in Chronic Obstructive Pulmonary Diseases, notes that the identification of exacerbations in AATD is critical because they are associated with disease progression and reduced quality of life. “Symptom-based definitions of…

doctor looking at tablet

New Consensus Classification Published on Systemic Mastocytosis Types, Diagnosis

A new International Consensus Classification (ICC) has been published on myeloid neoplasms, including systemic mastocytosis (SM), and acute leukemia. The report, published in Blood, represents a major revision since the last update in 2016. “Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction…


Bioinformatics Analysis Reveals New Potential Therapeutic Targets in PAH

A new bioinformatics study offers insight into the pathogenesis of pulmonary arterial hypertension (PAH) as well as 10 newly identified hub genes that could represent potential treatment targets for the disease. The study, published in the Canadian Respiratory Journal, employed multiple microarray analyses to provide a theoretical basis for future research in PAH. “Although basic…

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