New therapeutic strategies currently in development could inhibit the production of ceramides, a lipid molecule implicated in metabolic disease and long chain fatty acid oxidation disorders (LCFAOD). Scott Summers, PhD, reviewed how an overaccumulation of fat-derived molecules, as seen in obesity, physical inactivity, and LCFAODs, contributes to the tissue dysfunction that underscores many common metabolic…
A recent case report followed an 83-year-old woman who was admitted to the hospital for progressive extremity cyanosis and fatigue after exposure to cold.
Neuropathic symptoms may be at least partially reversible in patients with long chain fatty acid oxidation disorders (LCFAOD), according to new research. Speaking at the International Network for Fatty Acid Oxidation Research and Management (INFORM) Virtual Meeting held October 27-28, 2021, Sarah Grunert, MD, stated that neuropathic symptoms in patients with long chain 3-hydroxyacyl CoA…
A review article reveals that lung and liver transplantation have favorable outcomes in AATD patients with end-stage lung and liver diseases.
Lipids, which play a key role in the pathogenesis of multiple sclerosis, can be used as targets or carriers of treatment.
An increasing number of clinical studies have confirmed the utility of chemotherapy in treating malignancies of the biliary tract.
Researchers at the University of Pennsylvania highlight the improvements in disease modeling afforded by a molecular understanding of Alagille syndrome.
Cholangiocarcinoma (CCA) is an aggressive form of biliary malignancy with a dismal 5-year postoperative survival rate. The incidence of CCA is increasing globally, accounting for approximately 2% of all cancer-related deaths. As such, there is an urgent need for diagnostic and prognostic biomarkers to aid in early disease detection and help guide treatment. Recently, a…
Wearable exoskeletons, a form of robot-assisted therapy, improve satisfaction with gait training in patients with multiple sclerosis (MS) and their treating physiotherapists, according to a new cross-sectional study out of Madrid, Spain. Researchers at the Madrid Foundation against Multiple Sclerosis surveyed 54 study participants, including patients with MS and physiotherapists specializing in neurologic rehabilitation. Clinical…
