James Frederick

All articles by James Frederick

Scott Summers

Novel Therapeutics May Inhibit Ceramide Production in LCFAOD

New therapeutic strategies currently in development could inhibit the production of ceramides, a lipid molecule implicated in metabolic disease and long chain fatty acid oxidation disorders (LCFAOD).  Scott Summers, PhD, reviewed how an overaccumulation of fat-derived molecules, as seen in obesity, physical inactivity, and LCFAODs, contributes to the tissue dysfunction that underscores many common metabolic…


Neuropathic Symptoms Partially Reversible in LCFAOD, Expert Says

Neuropathic symptoms may be at least partially reversible in patients with long chain fatty acid oxidation disorders (LCFAOD), according to new research. Speaking at the International Network for Fatty Acid Oxidation Research and Management (INFORM) Virtual Meeting held October 27-28, 2021, Sarah Grunert, MD, stated that neuropathic symptoms in patients with long chain 3-hydroxyacyl CoA…

health test

The Role of MicroRNAs in the Pathogenesis, Diagnosis, and Treatment of Cholangiocarcinoma

Cholangiocarcinoma (CCA) is an aggressive form of biliary malignancy with a dismal 5-year postoperative survival rate. The incidence of CCA is increasing globally, accounting for approximately 2% of all cancer-related deaths. As such, there is an urgent need for diagnostic and prognostic biomarkers to aid in early disease detection and help guide treatment.  Recently, a…

wearable exoskeletons MS

Wearable Robotics Improve Satisfaction With Gait Training in Patients With MS

Wearable exoskeletons, a form of robot-assisted therapy, improve satisfaction with gait training in patients with multiple sclerosis (MS) and their treating physiotherapists, according to a new cross-sectional study out of Madrid, Spain.  Researchers at the Madrid Foundation against Multiple Sclerosis surveyed 54 study participants, including patients with MS and physiotherapists specializing in neurologic rehabilitation. Clinical…

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