Esteban Kosak MD

Esteban Kosak MD

Venezuelan Medical Doctor with teaching experience and national research prizes in the immunology field. Esteban currently works as a primary care physician in Caracas, Venezuela.

All articles by Esteban Kosak MD

high risk pregnancy

Term Pregnancy and Successful Delivery in a Patient With AATD

Pregnancy for patients with severe alpha-1 antitrypsin deficiency (AATD) should be considered on a case-by-case basis, a case report published in Archivos de Bronconeumonología suggests. Patients with AATD typically have high-risk pregnancies due to several possible complications. Although scarce studies describing pregnancy outcomes in patients with AATD exist, previous literature has suggested that due to the high…


AATD Treatment Benefits Neutrophil Adhesion

Treatment for alpha-1 antitrypsin deficiency (AATD) could deliver additional cellular benefits that modulate other factors in the physiopathology of the disease, according to an experimental study recently published in the American Journal of Respiratory Cell and Molecular Biology. Alpha-1 antitrypsin (AAT) augmentation therapy demonstrated in vitro antiinflammatory activity by diminishing controlled neutrophil adhesion, as reported…

genetic testing

Novel Genetic Profile Identified in Case of Systemic Mastocytosis

A novel genotype was identified in a patient with systemic mastocytosis (SM) and published in a case report in Cancer Genetics. “This case provides evidence that MCL [mast cell leukemia] can have wide spectrum of genetic abnormalities as well as accumulation of mutations in various genes including BRAF,” the authors said. The study demonstrated coexistent…

pompe disease

Newly Identified Airway Pathology Correlates With Pompe Disease Impairments

Glycogen pileup in the distal airway cells of Pompe disease (PD) may contribute to respiratory impairments in patients with the disease, a new study published in the FASEB Journal found. PD is a disorder in the glycogen hydrolyzation within the lysosomes due to alpha-glucosidase (GAA) deficiency. The disease includes skeletal, nervous, cardiac, and respiratory manifestations. Respiratory insufficiency…

preterm baby

Combining Neurological Assessments Detects Early Patterns of SMA

Combining 2 different neurological assessment tools could become an effective screening test for spinal muscular atrophy (SMA) in newborns, according to a new study recently published in the European Journal of Pediatrics. “Even in the absence of obvious clinical signs, a number of infants classically defined as presymptomatic, may have isolated minimal signs, such as…

Software developer

Proposed Bayesian Method Predicts Ventilation Distribution in CF

A new Bayesian method reduced the ventilation distribution in patients with cystic fibrosis (CF), as published in Respiratory Physiology & Neurobiology. This method used fewer breath cycles than lung clearance index (LCI) and correlated with ventilation magnetic resonance imaging (MRI), and was also important for clinical decision-making. Determining ventilation heterogeneity is essential because it is…

Central nervous system

Researchers Recommend Strategy for Managing MS With CNS Tumors

Disease-modifying therapies (DMTs) for patients with multiple sclerosis (MS) is desirable in patients with highly active and aggressive MS and concurrent central nervous system (CNS) tumors, a new study published in Neurological Sciences suggests. The clinical management of patients with simultaneous MS and CNS tumors is challenging due to several possible treatment limitations plus the intrinsic…

Tumor necrosis

Proposed MTC Grading System Combines Proliferative Activity and Necrosis

The International Medullary Thyroid Carcinoma Grading System (IMTCGS) appears to be superior to other grading systems for predicting disease-free survival (DFS) and overall risk stratification in patients with medullary thyroid carcinoma (MTC), according to a study recently published in Endocrine Pathology. “We suggest the implementation of the IMTCGS scheme in routine clinical practice: one of…

blood test tube

Are C-Reactive Protein Levels Required for Diagnosing AATD?

C-reactive protein measurement may not be necessary to diagnose alpha-1 antitrypsin deficiency (AATD) if patients are evaluated for alpha-1 antitrypsin (AAT) levels and undergo genotyping at the same time, according to a prospective observational analytic study published in the Clinical Respiratory Journal. For many years, it has been suggested to measure C-reactive protein levels in…

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