Laparoscopic hepatectomy (LH) for patients with intrahepatic cholangiocarcinoma (CCA) leads to better surgical outcomes with similar oncological and survival outcomes when compared to open hepatectomy (OH), according to a systematic review and meta-analysis published in the European Journal of Surgical Oncology. The meta-analysis found that patients with intrahepatic CCA who received LH had better surgical…
A 14-year-old male patient was diagnosed with cooccurring type 1 diabetes mellitus (DM1) and very long chain acyl-CoA dehydrogenase deficiency (VLCADD), a type of long chain fatty acid oxidation disorder (LCFAOD), as reported in a case study published in Clinical Biochemistry. The co-occurrence of both disorders requires careful balancing to avoid hyperglycemia and hypoglycemia. Hyperglycemia…
A new clinical trial, AVANCE1, is recruiting adult and pediatric patients with Duchenne muscular dystrophy (DMD) to investigate the safety, pharmacokinetics (PK), and pharmacodynamics of a novel antisense oligonucleotide called SQY51. The trial, sponsored by SQY Therapeutics and Biotrial, is recruiting up to 12 participants to initially receive escalating intravenous infusions of SQY51 every 2…
A case report of a mother and her children with familial medullary thyroid carcinoma (MTC) was presented as an ePoster at the 2023 International Meeting of Pediatric Endocrinology (IMPE 2023). A 32-year-old mother was diagnosed with metastatic MTC after progressive weakness of her extremities, weight loss, and dysarthria. She was found to have a TGC-TGG…
A prognostic index, called the geriatric prognostic index (GPI), was developed for older patients with diffuse large B-cell lymphoma (DLBCL) who are candidates for treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The new GPI outperformed the most widely used clinical prediction models, including the international prognostic index (IPI), the revised IPI (R-IPI), and…
Decrements in oculomotor ranges after repeated saccadic and pursuit movements may be a sensitive and specific tool for the diagnosis of myasthenia gravis (MG), according to a study published in the Journal of Neurology. Quantitative analysis of saccadic and smooth pursuit fatigability using video-oculography (VOG) was able to distinguish between patients with MG and healthy…
Wilson disease (WD) can increase the risk of miscarriage, premature birth, and perinatal mortality, but careful monitoring and management by medical professionals can improve quality of life and the chances of a successful pregnancy, according to a case series published in Medicine. In the case series, 3 of the 4 pregnancies in women with WD…
Patients with neuromyelitis optica spectrum disorder (NMOSD) are commonly misdiagnosed, leading to delays in treatment initiation, according to an international study published in Neurology and Therapy. The study, which analyzed clinical records from the United States, Germany, Italy, Brazil, South Korea, and China, found that roughly 25% of aquaporin-4 (AQP4) immunoglobulin G (IgG)-seropositive adults with…
Treatment with nusinersen (Spinraza®) suppresses some neuroinflammatory factors in patients with severe spinal muscular atrophy (SMA), according to a study published in Communications Medicine. The study found that levels of proinflammatory cytokines and neurotrophic factors were increased in the cerebrospinal fluid (CSF) of patients with SMA type 1 compared to patients with SMA type 2,…
People with primary progressive multiple sclerosis (pwPPMS) have a reduced number of memory and regulatory immune cells compared to healthy controls, according to a study published in Cells. During the study, it was observed that pwPPMS had lower numbers of central memory (CM; CD45RA−CCR7+) T cells expressing CD4+ and CD8+ as well as a reduction…
